• Rice Bran Molecules From Japan Underutilized In Modern Medicine

    Posted November 29, 2018: by Bill Sardi

    Kyoto, Japan (November 29, 2018):  While modern synthetic medicines treat symptoms of disease but fail to address their underlying cause and newly developed drugs don’t work as well as old ones, small molecules derived from rice bran (inositol, ferulic acid, gamma oryzanol, inositol hexaphosphate- IP6) address many of the root causes of illness as well as aging itself, which represents the majority of chronic maladies treated by modern medicine.

    So says health journalist Bill Sardi (Knowledge of Health, USA) who delivers a presentation in Kyoto, Japan this week at the 3rd International Symposium on Rice Science in Global Health. Sardi has written two books (The Iron Time Bomb and How To Live 100 Years Without Growing Old) about rice bran and health emanating from his trips to Japan.

    The efficacy of rice bran molecules to maintain health is derived from their ability to reduce accumulation and release of potentially toxic minerals such as unbound iron, copper and calcium and to facilitate the proper folding of proteins produced within living cells.

    The human body uses many molecules to bind to iron and copper (albumin, hemoglobin, ferritin, transferrin, lactoferrin) and copper (ceruloplasmin).  In a perfect state of health all minerals are bound and under control.  Unbound iron and copper generate oxidation that damages cells, tissues and organs.  The process of binding minerals is called chelation (key-la-shun).

    Molecules derived from rice bran represent missing nutrients in Western processed foot diets that are devoid of whole grains.  Bran is part of grain husk separated from flour after milling.  While high fiber diets are widely recommended to promote health, fiber from bran is exclusively different from fruits like apples and pears.

    Maladies that result from overmineralization (rust from iron, calcifications from calcium) occur in iron/copper-rich organs such as the heart, kidneys, brain, liver and eyes.

    Overmineralization and aging

    More specifically, Sardi says widely extolled calorie restricted diets that prolong the years of health and life in laboratory animals (doubling healthspan and lifespan) are not effective because of limited calories but because such a diet provides less iron and calcium.

    Sardi claims the human body doesn’t begin to age till after full growth is achieved (around age 18) and then begins to accumulate iron and calcium that was needed during youth to produce new bone and make new red blood cells.  With advancing age excess iron accumulates, particularly in the liver, brain, eyes and red blood cells.  Calcium is lost from bone and accumulates and hardens in arteries, kidneys, skin and other organs.

    Sardi calls this the Overmineralization Theory of Aging.  The rate of aging correlates with the rate of deposition and release of iron, copper and calcium into tissues.

    Nature’s master mineral chelator is IP6 found in bran.  IP6 serves as a backstop to bind up iron, copper and calcium when the mineral control system is overwhelmed.

    When a bran factor (IP6) is added to the diet less cellular debris accumulates as lipofuscin, which is known as an aging pigment.

    Sardi says there is no biological aging during the growth years because iron and calcium are needed to produce new bone and new red blood cells.  Up to age 18 or so humans only have birthdays and are not aging biologically, says Sardi.

    Differences between males and females

    After full growth is achieved women avoid overmineralization via monthly iron losses in menstrual flow and avoid over-calcification by donating calcium to their offspring.   After menopause women begin to age faster because they begin to accumulate iron and calcium.

    Full-grown males have no way to control iron other than loss in sweat and will have double the amount of iron and four times as much calcium stored in their body at age 40 compared to equally-aged females and experience twice the risk for diabetes, cancer and heart disease compared to an equally-aged female.  If women undergo an early hysterectomy they develop the same disease risks as males.

    IP6: Superior antioxidant

    The iron-binding qualities of rice bran IP6 are akin to blood letting.  Sardi notes that IP6 is the only antioxidant to both quell oxygen and iron-induced oxidation.  This is because IP6 cleaves to hemoglobin where normally iron and oxygen are attached in red blood cells.  While there are many powerful antioxidants in nature, none have the unique qualities of IP6, says Sardi.

    IP6 cure for stiff arteries

    Calcification of tissues and organs is yet another problem addressed by IP6.  The body shows signs of calcification in the kidneys, which results in calcium stones.  The aorta, the first blood vessel outside the heart, stiffens due to calcification, which causes the heart to pump harder, that in turn results in high blood pressure.  This is the leading cause of hypertension in human populations where bran (IP6) is lacking in the diet.  IP6 has been demonstrated to eradicate aortic calcifications and has been called “the best cure.”

    IP6 to overcome western diets

    Sardi notes that countries where iron-rich red meat and calcium-rich dairy products are commonly consumed (North America, Scandinavian countries, New Zealand) have more need to fortify IP6 in their diets or take IP6 dietary supplements, says Sardi.

    Western processed food diets provide little IP6 (~250 milligrams/day) whereas diets rich in nuts, seeds (sesame), whole grain (bran)-rich diets provide up to 1500 milligrams of IP6 per day.  The optimal health promoting effects of IP6 are achieved when IP6 is fortified or supplemented in the diet.

    IP6 is superior to any medication to cleanse the kidneys of calcium stonesIP6 is the most effective liver cleanser available.

    IP6 also decalcifies the aorta, the first blood vessel outside the heart.  Aortic stiffness due to calcification is cited as the primary reason for high blood pressure in countries that consume processed foods.  Lamentably, IP6 goes unutilized in western medicine, says Sardi.

    Other rice bran molecules

    Inositol, another rice bran nutrient, is now being used therapeutically in Italy to normalize thyroid hormone levels and quell glandular inflammation (thyroiditis).  Inositol has also been cited to relieve anxiety.  Infant feeding formulas for prematurely born babies contain inositol as a lung surfactant to alleviate lung distress.

    Ferulic acid has strong sun-blocking properties to filter out potentially harmful UV rays and is being used in anti-aging skin products.  Ferulic acid has been shown to improve sun protection factor (SPF) in topical sun blocking products.

    Rice bran gamma oryzanol is now proposed as a promising prophylactic against elevated blood sugar and obesity.  Remarkably, gamma oryzanol reduces preference for fatty foods via its ability to suppress the dopamine brain reward signal.   Oryzanol could be the breakthrough in middle-age weight gain and metabolic disorders.

    Gene editing

    Given that rice bran fractions include waxes (policosanol) and gamma oryzanol, a new revelation is that these natural molecules, when properly solubilized, may re-program defective genes via their proposed ability to read through stop signals (codons) in the assemblage of proteinsOne such stop codon is found in the GULO gene, a gene that facilitates the endogenous protein (enzymatic) synthesis of vitamin C from blood glucose, a property found in most animals but not humans.

    Natural molecules have only recently been recognized to correct epigenetic flaws, such as escin from horse chestnut and resveratrol from grapes.  Restoration of vitamin C synthesis in humans would be a monumental advancement in health promotion.

    The sponsor of the symposium is Tsuno Foods & Rice Company of Wakayama, Japan and is the leading supplier of rice bran molecules in the world.  To learn more about rice bran molecules, visit the scientific presentation page for the symposium or visit Facebook.  ####

    Bill Sardi is a health journalist and nutraceutical formulator writing at KnowledgeOfHealth.com.  He writes from La Verne, California.  Email: bsardi@aol.com

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