• Researchers Uncover The Cause And Cure For Breast & Prostate Cancer

    Posted March 18, 2011: by Bill Sardi

    Knowledge of Health, Inc. (March 18, 2011) – Researchers at the Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, now explain how an imbalance in estrogen metabolism leads to improper repair of broken DNA which in turn produces gene mutations that promote breast, prostate and other cancers.

    These researchers then go on to identify two natural molecular antidotes, a sulfur compound (N-acetyl cysteine) and a molecule found in red wine (resveratrol), which can completely block the initiation of these cancers. Both of these molecules are widely available as dietary supplements. When used together these antioxidants completely abolished the formation of DNA-adducts (cancer-causing chemicals that are coupled with DNA), which is the initiating step in these cancers.

    Women with breast cancer and men with prostate cancer, as well as men with non-Hodgkins’ lymphoma, all have relatively high urine and blood serum levels of estrogen-DNA adducts. Or estrogen-DNA adducts may be normal but its ratio to other liver breakdown molecules (metabolites) of estrogen is high.

    Since breast tissue can produce estrogen locally, the breast is extra vulnerable to become cancerous. This may explain why post-menopausal women who do not produce estrogen from their ovaries still develop breast cancer. Estrogen levels in breast tissue of cancer patients are 50-100 times greater than blood levels.

    There is strong evidence that estrogen promotes cancer. For example, when laboratory rats are implanted with estrogen + testosterone, 100% of these animals will develop prostate cancer compared to 40% when animals are implanted with testosterone only.

    There is even more evidence that estrogen is involved in breast and prostate tumors. A study of 2018 women found those women who consumed mushrooms in their diet had a 50% lower incidence of breast cancer than women who did not consume mushrooms. Also, the incidence of breast cancer dropped 90% among women who consumed both mushrooms and green tea. Mushrooms contain plant chemicals that inhibit the enzyme (aromatase) necessary to produce estrogen. #### – © 2011 Bill Sardi, Knowledge of Health, Inc. Not for posting on other websites.

    DNA adducts chart

    Chart shows level of cancer-causing DNA adducts when various concentrations of N-acetyl cysteine (AC) and/or resveratrol (RES) are added to a lab dish of breast cells.


    Abstract from the National Library of Medicine

    Journal Steroid Biochemistry Molecular Biology 2011 Mar 9. [Epub ahead of print]

    Unbalanced Metabolism of Endogenous Estrogens in the Etiology and Prevention of Human Cancer.

    Cavalieri EL, Rogan EG

    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805; Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805.

    Abstract

    Among the numerous small molecules in the body, the very few aromatic ones include the estrogens and dopamine. In relation to cancer initiation, the estrogens should be considered as chemicals, not as hormones. Metabolism of estrogens is characterized by two major pathways. One is hydroxylation to form the 2- and 4- catechol estrogens, and the second is hydroxylation at the 16α position. In the catechol pathway, the metabolism involves further oxidation to semiquinones and quinones, including formation of the catechol estrogen-3,4-quinones, the major carcinogenic metabolites of estrogens. These electrophilic compounds react with DNA to form the depurinating adducts 4-OHE(1)(E(2))-1-N3Ade and 4-OHE(1)(E(2))-1-N7Gua. The apurinic sites obtained by this reaction generate the mutations that may lead to the initiation of cancer. Oxidation of catechol estrogens to their quinones is normally in homeostasis, which minimizes formation of the quinones and their reaction with DNA. When the homeostasis is disrupted, excessive amounts of catechol estrogen quinones are formed and the resulting increase in depurinating DNA adducts can lead to initiation of cancer. Substantial evidence demonstrates the mutagenicity of the estrogen metabolites and their ability to induce transformation of mouse and human breast epithelial cells, and tumors in laboratory animals. Furthermore, women at high risk for breast cancer or diagnosed with the disease, men with prostate cancer, and men with non-Hodgkin lymphoma all have relatively high levels of estrogen-DNA adducts, compared to matched control subjects. Specific antioxidants, such as N-acetylcysteine and resveratrol, can block the oxidation of catechol estrogens to their quinones and their reaction with DNA. As a result, the initiation of cancer can be prevented.

    Copyright © 2011. Published by Elsevier Ltd.

    PMID: 21397019

     

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3 Responses to “Researchers Uncover The Cause And Cure For Breast & Prostate Cancer”

  1. Sharon Says:
    March 21st, 2011 at 11:38 pm

    Bill,, it’s great to have you back on line!! I hope you can answer this question. I have the family history of breast disease and myself am overweight(currently on Mediterannean diet and losing) and no doubt estrogen dominant. I am allergic to grape seed oil which gives me horrible migraines and wondering if resveratrol would do the same? I will get the NAC immediately. I have been taking pomegranate extract for carotid blockages and that gives me a headache also but I’m afraid to stop it.

    KnowledgeOfHealth.com:

    frontal headache is likely from anemia. All iron-binding molecules found in grapes, pomegranates, bran, berries, would likely result in the same problem. Take vitamin C with meals to remedy anemia. – Bill Sardi

  2. Keith Says:
    April 1st, 2011 at 5:51 pm

    Sorry, dont understand your logic re estrogen. Here your recommending to supress it yet your article on calcium in post menopausal women recommends they take hormone therapy to ensure calcium absorption.

    KnowledgeOfHealth.com:

    There is a distinction between taking supplemental estrogen once menopause sets in (decline in estrogen production in the ovaries) and the local production of estrogen in fatty tissue in the breast. Fat cells (adipocytes) can produce estrogen on their own. It’s easy to see, women have two globs of fatty tissue on their chest. Estrogen can release iron, like for growth of a baby. When estrogen is released in the breast in post-menopausal women it has nowhere to go (like feeding babies) and there is no longer any monthly menstrual flow to remove iron, so it accumulates and is release in an unbound (toxic) form to create gene mutations and eventually tumors. – Bill Sardi

  3. Craig DeForest Says:
    July 23rd, 2011 at 8:45 am

    Bill,

    This is so wonderful! Now I have searched for other articles on NAC and resveratrol, and found them. One is from PubMed, written by NIH in Oct. of 2010.

    So my question is, what is the world do these people think they are doing by not making us more aware of the DISCOVERED benefits of this combo? Their response seems always to be, “Our mission is to first do no harm.” They carry this to such an extreme!

    Hell, their “discovery” that vitamin C kills cancer cells was to be followed by “other research.” It has now been almost 6 years, and no further news from them? ! ?

    KnowledgeOfHealth.com:

    The problem is that these discoveries never get to be applied science because the medical care delivery system is calculating how much profit such a discovery would generate. There is an insurance billing code for surgery, radiation and chemo. When you have breast cancer centers, they have to churn a lot of patients through potentially harmful mammographic screening, to find a few cases to treat. The false assumption is that all breast tumors must be detected and treated. But a few years back consecutive autopsies were performed on women who had died of a variety of causes, and breast tumors were found in many of them, but they didn’t die from these tumors. Women are fearful. The more invasive you get with these tumors, the more likely they will spread. The NAC/resveratrol approach goes largely unused. –Bill Sardi

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