• Behind The Curtains, A Cancer Cure

    Posted January 12, 2019: by Bill Sardi

    A researcher believes he has a novel cure for cancer.  In fact, a lengthy patent explains the rationale for the cure.  But in doing so, it reveals much more.

    First this researcher notes that the lifetime cancer risk is 40% in humans and just 4% in virtually all other large-bodied long-lived species.  Why?

    In the presentation of his patent-applied-for cure it is noted that the 2-year survival observed in cancer patients over the past 27 years is a disappointing 7%.  The reason given is telling.

    Virtually all of the cancer therapies and studies start with animal laboratory data in mice.  And, as this cancer researcher properly notes, these studies have resulted in the creation of drugs that treat cancer in mice, not humans.  Therefore, the “extent to which such cancer drugs also work in humans is thus likely to be accidental.”  [Endocrine-Related Cancer Nov. 2018; Oct 2018; Oct 2018]

    The researcher says there is not a single drug in use in cancer today that did not fundamentally depend upon the use of mice in its discovery and development… predicated on there being a universal mechanism of action of the p53 tumor suppressor gene.”

    Our unnamed cancer researcher describes the p53 gene as the “cancer kill switch.”  The p53 gene slows the cell renewal cycle, giving more time for DNA repair.  And p53 can trigger cancer cell death (apoptosis) via activation of a storm of oxygen radicals.  P53 normally keeps a lid on oxidation.

    P53 is intimately involved with DHEA, a hormone secreted by the adrenal glands that is a precursor for sex hormones and counters cortisol, an adrenal stress hormone.  Of interest, high dose vitamin C (4000 mg) limits cortisol (stress) and aids in maintaining normal levels of DHEA.  [Annals NY Academy Science 1987]

    This researcher’s answer to cancer is to consume mega-dose DHEA, which may induce numerous side effects, skin rash, fever, mood decline, vulnerability to infections (eye and ear), nerve problems (lower legs) and loss of melanin skin pigmentation.  Then counter mega-dose DHEA side effects with an array of nutrients: coenzyme Q10, folic acid, potassium nitrate to restore nitric oxide gas, and a form of vitamin E (tocotrienols) along with SAMe, melatonin, vitamin B6 (as P5P) to counter mental depression that results from enzyme (monoamine oxidase) inhibition, and finally vitamin C.  It is vitamin C that is of acute interest.

    Inactivation of the cancer kill switch (p53 gene) induces a rapid catastrophic increase in oxygen radicals by the inhibition of an enzyme (glucoase-6-phsphate dehydrogenase -G6PC) that requires a high concentration of DHEA, in order to kill cancer cells.  Our researcher says this is the kill switch in which cell death is triggered by the inactivation of p53 that has been hiding in plain sight but kept hidden for many years.

    In the absence of vitamin C, due to universal genetic flaw in all humans who do not internally synthesize vitamin C as most other animals do, DHEA is in short supply and the cancer kill switch is negated.  So our cancer researcher proposes to flood the body with supplemental DHEA and overcome its side effects with a multitude of other nutrients in a complicated Rube Goldberg approach to conquer cancer.  Why not flood the body with vitamin C instead?

    Not to ridicule of this overcomplicated cure, but one wonders how well a patient would comply with taking all those pills over an adult lifespan?   This approach is not just to cure diagnosed cancers but to prevent them en masse in human populations.  A normalization of living tissues would be preferred over cure as it would relegate cancer to a relatively rare disease says our researcher.  That means putting millions of people on ten pills a day throughout their adult lifespan to normalize their cancer risk to that of other animals (from 40% to 4%).

    I guess that is one way of abolishing cancer.  Of course another simpler way would be to restore internal vitamin C synthesis in humans, if that is possible. (More on this below.)

    Our cancer researcher, using reverse logic, says the evolutionary gene mutation that resulted in the inability of humans to internally produce vitamin C served in a backwards way to “bring the necessary kill switch tumor suppression into existence.” (??). That is kind of like saying evolution brought about a disease so a cure could be realized, if that makes any sense.

    In laboratory mice that have been experimentally altered so they don’t internally produce vitamin C as most other animals do, the restoration of vitamin C to produce blood levels similar to naturally-secreting mice, slows cancer growth.  [Cancer Medicine 2014]

    The prospect of restoring vitamin C levels via dietary supplementation to that of a naturally secretion state has been demonstrated in lab animals whose vitamin C gene (gulonolactone oxidase gene) was inactivated.  The healthy lifespan of these genetically altered mice was restored when given supplemental vitamin C.  [Aging 2016]

    Instillation of vitamin C into mice that have been implanted with tumors transiently raises tissue levels of hydrogen peroxide that selectively kills cancer cells but almost magically does not produce hydrogen peroxide in blood where it would harm red blood cells. [Proceedings National Academy of Sciences 2008]

    Our cancer researcher fails to emphasize the major difference between laboratory mice and humans is that humans don’t internally produce vitamin C as mice do.  [Frontiers Oncology 2014] Ideally, guinea pigs should be used in laboratory experiments because they have the same gene mutation as humans and cannot internally synthesize vitamin C.  [Current Genomics 2011]. However, mice can be genetically altered to mimic the predicament humans are in via inactivation of the gene that makes the final enzyme required to convert blood sugar to ascorbate (vitamin C).  In humans a state of chronic vitamin C shortage that cannot be fully restored without repeated supplementation throughout the day (500 mg every 4-6 hours).  However, even such aggressive vitamin C supplementation doesn’t produce 24/7 synthesis as humans once produced prior to a universal gene mutation.

    If there an obvious difference between other large animals and humans it is the inability to internally synthesize ascorbate (vitamin C) from their liver (or from the kidneys in some species).

    High dose DHEA prolongs the life of cancer stricken old dogs and decreases tumor volume.  Our researcher’s patent application shows the results of this DHEA-based therapy on old dogs, which are remarkable.  [US Patent Application 2017/0007619 A1].  Most of the dogs treated with mega-dose DHEA suffered from side effects (skin rash, fever, ear infection, fluid retention, eye inflammation, depigmentation of skin) which were abolished with supplemental nutrients. Of 13 dogs treated, tumors shrank in size and 12 of 13 survived 52 weeks whereas none survived without DHEA + accompanying nutrients!  So as complicated as this cure is, it is very compelling.

    Of course, dogs also synthesize vitamin C as do laboratory mice, which sets them apart from humans.  So dogs like mice are not biologically equivalent to humans from a vitamin C standpoint.  But old dogs do lose capacity to synthesize vitamin C and suffer the health consequences.

    Of course, our researcher proposes a novel cure, but for reference, a very similar study published in 1997 that spelled out a cure for cancer among p53-deficient mice via DHEA supplementation suggests his treatment is not as novel as claimed.  The avoidance of DHEA side effects is the novel part of this patent application.  And it also reveals this convincing cancer cure has been kept under wraps for some time.  [Carcinogenesis 1997].  Our unidentified researcher states he is willing to conditionally transfer his patent application to the National Cancer Institute.  But health authorities haven’t run with this idea that was first published over two decades ago.

    Is modern medicine so averse to utilizing vitamin C that it has let cancer wreak its havoc for decades unabated?

    What is more compelling is that there is now the prospect of restoring natural function to the GULO (gulonolactone oxidase enzyme) gene in humans via molecular gene editing.  An olive extract has been found to double vitamin C blood levels without dietary or supplemental vitamin C intake.  In a preliminary proof-of-principle test, a commercial nutraceutical that provides this olive extract + immune-boosting cofactors (zinc, vitamins A& D) has demonstrated an ability to demonstrably raise urine levels of vitamin C, particularly when biological stress was induced.  [Formula-216.com]. Restoration of 24/7 vitamin C synthesis in humans may be at hand.  Will the lifetime risk for cancer then revert back to 4%, down from 40%, as observed in other large animals?

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