• Dietary Intake Of Phytate (IP6) Reduces Stiffening Of Aorta And Has Other Profound Health Effects

    Posted September 9, 2015: by Bill Sardi

    IP6 phytate is an overlooked nutritional factor that is protective against stiffening (calcification) of the first blood vessel (aorta) outside the heart. Stiffening of the aorta is associated with higher systolic (pumping) blood pressure.

    The dietary intake of IP6 was recently measured as determined by excretion in urine among senior adults, with the following results:

    Health Effects Of Dietary IP6 Among Senior Adults
    (Urinary Levels of IP6 Phytate In Adults ~age 70 years)

    Amount of IP6 in urine ->




    Calcification of aorta




    Adult Diabetes




    High cholesterol




    Bone loss




    Source: PLoS One August 31, 2015

    IP6 phytate (inositol hexaphosphate) was first identified by Dr. Stephen Seely in 1991 as a natural agent that helps retain elasticity of arteries, particularly the aorta, which is prone to calcification. [International Journal Cardiology 1991]

    While beans, peanuts, peas, lentils, corn, oats, rice and walnuts provide signification amounts of phytate (2-3% by dry weight), rice bran is the most abundant dietary source of IP6. For adults who wish to eradicate calcifications in tissues throughout their body, the consumption of IP6 rice bran extract is suggested as it is 70% IP6.



    Rice bran 2.6-8.7%
    Wheat bran 2.1-3.9%
    Sesame seeds 1.4-5.4%
    Beans 0.6-2.4%
    Walnuts 0.2-6.7%
    IP6 rice bran extract 70.0%

    Source: Molecular Nutrition Food Research Sept 2009

    IP6 is a miraculous molecule for other reasons:

    • The puzzle of how double-sided DNA breaks are repaired was unraveled in 2000 when it was demonstrated that IP6 facilitates double-strand DNA break repair. [Cell Sept 2000]
    • IP6 elevates the activity of a type of white blood cells known as natural killer cells. [World Journal Gastroenterology Aug 2005]
    • IP6 inhibits kidney stone formation [Anticancer Research 1999]
    • IP6 inhibits blood clots. [Blood Aug 22, 2013]
    • IP6 is necessary for release of insulin from the pancreas. [Science 1997]
    • IP6 inhibits tumor growth. [Pol. Merkur Lekarski 2012]
    • IP6 phytate provides complete protection against brain toxicity induced by beta amyloid deposits in the brain. [Journal Alzheimer’s Disease 2011]
    • IP6 is a strong metal binding (chelating) agent. [Tsuno Foods]
    • IP6 phytate binds to heavy metals, including copper. [Applied Biochemistry Biotechnology 1997] This may be the reason why IP6 phytate is considered a therapeutic agent in the control of diabetes. [Drugs 2011]
    • IP6 protects against fatty liver. [Anticancer Research 1999]
    • IP6 is generally recognized as safe (GRAS status) by the Food & Drug Administration. IP6 is deemed to be a safe, non-toxic metal chelator. [Environmental Molecular Mutagenesis 2001]

    IP6 phytate is extracted from rice bran by the Tsuno Foods & Rice Co., Wakayama, Japan, and is sold under various brand names.©2015 Bill Sardi, Knowledge of Health, Inc.

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